Senior Research Scientist

My client is using unique molecular simulation and quantum-physics based modelling technology to accelerate medication discovery for difficult disease targets. In addition to developing pharmaceuticals that are safer and more effective, they are also cutting down on the time and money required to find new drug possibilities. They are looking for a highly qualified and driven Research Scientist with experience in molecular modelling, physical chemistry, and proteins for drug creation to join their vibrant team.

The successful candidate will play a crucial role in our mission to create novel pharmaceutical compounds and advance their understanding of their interactions with biological systems.

Responsibilities:

• Model and simulate how possible medication candidates interact with biological targets like proteins, enzymes, or receptors using computational approaches.
• Create and configure simulations using molecular dynamics according to the goals of the study.
• Examine and evaluate how drug candidates bind to target proteins, considering thermodynamics and binding affinities.
• Conduct experiments and computational simulations to understand the physicochemical properties of drug molecules and their impact on pharmacokinetics and pharmacodynamics.
• Use computational methods and protein structures to inform the logical design of novel medicinal drugs.
• Prepare tiny compounds by chemical synthesis, purification, and characterisation for simulations or studies.
• Work together with diverse groups of scientists, biologists, medicinal chemists, and other experts to incorporate computational results into drug discovery initiatives.
• Assist in the writing of reports, research papers, and patents pertaining to the development and discovery of new drugs.

Background:

• PhD in physical chemistry, biophysics, theoretical chemistry, , or a similar discipline with an emphasis on molecular modelling and drug design.
• Proficient knowledge of protein-ligand interactions, computational chemistry, and molecular modelling.
• Multiple years’ experience in a Biotechnology/Pharmaceutical/CRO environment.
• Experience with atomistic and AMOEBA force fields, and their application in molecular simulations and drug discovery.
• Expertise in utilising tools and software for drug discovery, such as structure-based drug design platforms, docking software (such Schrödinger Suite and AutoDock), and molecular dynamics simulations.
• Proficiency in Small Molecules and interactions, as well as RNA structural dynamics and RBP.
• Strong problem-solving and analytical skills, especially in the context of drug design.
• Excellent written and oral communication skills, with the ability to communicate complex scientific concepts to diverse audiences.
• Demonstrated record of research publications and contributions to drug discovery.
• Ability to work independently and collaboratively within a team.

I strongly recommend you apply if you are a highly motivated scientist with experience in proteins for drug design, physical chemistry, and molecular modelling and if you are driven to have a big influence on drug discovery. Become a member of a team and participate in their innovative medication development journey.

Following your application Filipa Englefield, a specialist Biotech will discuss the opportunity with you in detail. She will be more than happy to answer any questions relating to the industry and the potential for your career growth. The conversation can also progress further to discussing other opportunities, which are also available right now or will be imminently becoming available. This position has been highly popular, and it is likely that it will close prematurely. We recommend applying as soon as possible to avoid disappointment.

Please click ‘apply’ or contact Filipa Englefield for any further information.

Filipa Englefield

Recruitment Consultant - EMEA

Email: fenglefield (@) barringtonjames.com